A quantitative structure-activity relationship (QSAR) study of some diaryl urea derivatives of B-RAF inhibitors

A quantitative structure-activity relationship (QSAR) study of some diaryl urea derivatives of B-RAF inhibitors

In the current study, both ligand-based molecular docking and receptor-based quantitative structure activity relationships (QSAR) modeling were performed on 35 diaryl urea derivative inhibitors of V600E B-RAF. In this QSAR study, a linear (multiple linear regressions) and a nonlinear (partial least...

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Bibliographic Details
Main Authors: Sedighe Sadeghian-Rizi, Amirhossein Sakhteman, Farshid Hassanzadeh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
qsar; b-raf inhibitors; diaryl urea; docking; multiple linear regressions; pls-ls-svm
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2016;volume=11;issue=6;spage=445;epage=453;aulast=Sadeghian-Rizi

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http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2016;volume=11;issue=6;spage=445;epage=453;aulast=Sadeghian-Rizi

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