Optimized immunosuppression to prevent graft failure in renal transplant recipients with HLA antibodies (OuTSMART): a randomised controlled trialResearch in context

Optimized immunosuppression to prevent graft failure in renal transplant recipients with HLA antibodies (OuTSMART): a randomised controlled trialResearch in context

Summary: Background: 3% of kidney transplant recipients return to dialysis annually upon allograft failure. Development of antibodies (Ab) against human leukocyte antigens (HLA) is a validated prognostic biomarker of allograft failure. We tested whether screening for HLA Ab, combined with an interv...

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Bibliographic Details
Main Authors: Dominic Stringer, Leanne Gardner, Olivia Shaw, Brendan Clarke, David Briggs, Judith Worthington, Matthew Buckland, Guilherme Danzi, Rachel Hilton, Michael Picton, Raj Thuraisingham, Richard Borrows, Richard Baker, Keith McCullough, John Stoves, Mysore Phanish, Sapna Shah, Kin Yee Shiu, Stephen B. Walsh, Aimun Ahmed, Waqar Ayub, Janet Hegarty, Rose Tinch-Taylor, Evangelos Georgiou, Natalie Bidad, Ayşenur Kılıç, Zoe Moon, Robert Horne, Paul McCrone, Joanna Kelly, Caroline Murphy, Janet Peacock, Anthony Dorling
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:EClinicalMedicine
Subjects:
Kidney transplantation
HLA antibodies
Optimised immunosuppression
Stratified medicine
Kidney allograft failure
Online Access:http://www.sciencedirect.com/science/article/pii/S258953702200548X

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http://www.sciencedirect.com/science/article/pii/S258953702200548X

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