BDNF activates mTOR to regulate GluR1 expression required for memory formation.

BDNF activates mTOR to regulate GluR1 expression required for memory formation.

BACKGROUND:The mammalian target of Rapamycin (mTOR) kinase plays a key role in translational control of a subset of mRNAs through regulation of its initiation step. In neurons, mTOR is present at the synaptic region, where it modulates the activity-dependent expression of locally-translated proteins...

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Bibliographic Details
Main Authors: Leandro Slipczuk, Pedro Bekinschtein, Cynthia Katche, Martín Cammarota, Iván Izquierdo, Jorge H Medina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2695538?pdf=render

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http://europepmc.org/articles/PMC2695538?pdf=render

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