Targeted removal of the FA2 site on human albumin prevents fatty acid–mediated inhibition of Zn2+ binding

Zinc is required for virtually all biological processes. In plasma, Zn2+ is predominantly transported by human serum albumin (HSA), which possesses two Zn2+-binding sites of differing affinities (sites A and B). Fatty acids (FAs) are also transported by HSA, with seven structurally characterized FA-...

Full description

Bibliographic Details
Main Authors:	Dongmei Wu, Stephen J. Hierons, Sirilata Polepalli, Michal Gucwa, Remi Fritzen, Michal Markiewicz, Juan Sabín, Wladek Minor, Krzysztof Murzyn, Claudia A. Blindauer, Alan J. Stewart
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Series:	Journal of Lipid Research
Subjects:	13C-NMR allosteric interaction free fatty acids isothermal titration calorimetry serum albumin zinc
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227524000658

Internet

http://www.sciencedirect.com/science/article/pii/S0022227524000658

Targeted removal of the FA2 site on human albumin prevents fatty acid–mediated inhibition of Zn2+ binding

Internet

Similar Items