The World of GPCR dimers – Mapping dopamine receptor D2 homodimers in different activation states and configuration arrangements

The World of GPCR dimers – Mapping dopamine receptor D2 homodimers in different activation states and configuration arrangements

G protein-coupled receptors (GPCRs) are known to dimerize, but the molecular and structural basis of GPCR dimers is not well understood. In this study, we developed a computational framework to generate models of symmetric and asymmetric GPCR dimers using different monomer activation states and iden...

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Bibliographic Details
Main Authors: Beatriz Bueschbell, Pedro R. Magalhães, Carlos A.V. Barreto, Rita Melo, Anke C. Schiedel, Miguel Machuqueiro, Irina S. Moreira
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
G protein-coupled receptor (GPCRs)
Dopamine receptor D2
Homodimers
Dimer interface
Crosstalk
Selectivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023003069

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http://www.sciencedirect.com/science/article/pii/S2001037023003069

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