Correlations between the alpha-Gal antigen, antibody response and calcification of cardiac valve bioprostheses: experimental evidence obtained using an alpha-Gal knockout mouse animal model

Correlations between the alpha-Gal antigen, antibody response and calcification of cardiac valve bioprostheses: experimental evidence obtained using an alpha-Gal knockout mouse animal model

IntroductionPreformed antibodies against αGal in the human and the presence of αGal antigens on the tissue constituting the commercial bioprosthetic heart valves (BHVs, mainly bovine or porcine pericardium), lead to opsonization of the implanted BHV, leading to deterioration and calcification. Murin...

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Bibliographic Details
Main Authors: Filippo Naso, Andrea Colli, Peter Zilla, Antonio Maria Calafiore, Chaim Lotan, Massimo A. Padalino, Giulio Sturaro, Alessandro Gandaglia, Michele Spina
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
αGal antigen
knockout mouse model
bioprosthetic heart valves
polyphenols
calcification
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1210098/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1210098/full

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