A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.

Bibliographic Details
Main Authors: Xiao-Feng Zheng, Sanket S. Acharya, Katherine N. Choe, Kumar Nikhil, Guillaume Adelmant, Shakti Ranjan Satapathy, Samanta Sharma, Keith Viccaro, Sandeep Rana, Amarnath Natarajan, Peter Sicinski, Jarrod A. Marto, Kavita Shah, Dipanjan Chowdhury
Format: Article
Language:English
Published: Nature Portfolio 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12084-x

Internet

https://doi.org/10.1038/s41467-019-12084-x

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