A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1
Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12084-x |
| _version_ | 1819036087052402688 |
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| author | Xiao-Feng Zheng Sanket S. Acharya Katherine N. Choe Kumar Nikhil Guillaume Adelmant Shakti Ranjan Satapathy Samanta Sharma Keith Viccaro Sandeep Rana Amarnath Natarajan Peter Sicinski Jarrod A. Marto Kavita Shah Dipanjan Chowdhury |
| author_facet | Xiao-Feng Zheng Sanket S. Acharya Katherine N. Choe Kumar Nikhil Guillaume Adelmant Shakti Ranjan Satapathy Samanta Sharma Keith Viccaro Sandeep Rana Amarnath Natarajan Peter Sicinski Jarrod A. Marto Kavita Shah Dipanjan Chowdhury |
| author_sort | Xiao-Feng Zheng |
| collection | DOAJ |
| description | Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage. |
| first_indexed | 2024-12-21T07:59:56Z |
| format | Article |
| id | doaj.art-2c564c99951247baadb473f227a8cb95 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T07:59:56Z |
| publishDate | 2019-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2c564c99951247baadb473f227a8cb952022-12-21T19:10:55ZengNature PortfolioNature Communications2041-17232019-09-0110111310.1038/s41467-019-12084-xA mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1Xiao-Feng Zheng0Sanket S. Acharya1Katherine N. Choe2Kumar Nikhil3Guillaume Adelmant4Shakti Ranjan Satapathy5Samanta Sharma6Keith Viccaro7Sandeep Rana8Amarnath Natarajan9Peter Sicinski10Jarrod A. Marto11Kavita Shah12Dipanjan Chowdhury13Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Chemistry and Purdue University Center for Cancer Research, Purdue UniversityDepartment of Cancer Biology, Dana-Farber Cancer InstituteDepartment of Chemistry and Purdue University Center for Cancer Research, Purdue UniversityDepartment of Cancer Biology, Dana-Farber Cancer InstituteDepartment of Chemistry and Purdue University Center for Cancer Research, Purdue UniversityEppley Institute for Research in Cancer, University of Nebraska Medical CenterEppley Institute for Research in Cancer, University of Nebraska Medical CenterDepartment of Cancer Biology, Dana-Farber Cancer InstituteDepartment of Cancer Biology, Dana-Farber Cancer InstituteDepartment of Chemistry and Purdue University Center for Cancer Research, Purdue UniversityDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolRegulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.https://doi.org/10.1038/s41467-019-12084-x |
| spellingShingle | Xiao-Feng Zheng Sanket S. Acharya Katherine N. Choe Kumar Nikhil Guillaume Adelmant Shakti Ranjan Satapathy Samanta Sharma Keith Viccaro Sandeep Rana Amarnath Natarajan Peter Sicinski Jarrod A. Marto Kavita Shah Dipanjan Chowdhury A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1 Nature Communications |
| title | A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1 |
| title_full | A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1 |
| title_fullStr | A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1 |
| title_full_unstemmed | A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1 |
| title_short | A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1 |
| title_sort | mitotic cdk5 pp4 phospho signaling cascade primes 53bp1 for dna repair in g1 |
| url | https://doi.org/10.1038/s41467-019-12084-x |
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