Reconstruction of a catalogue of genome-scale metabolic models with enzymatic constraints using GECKO 2.0

Abstract Genome-scale metabolic models (GEMs) have been widely used for quantitative exploration of the relation between genotype and phenotype. Streamlined integration of enzyme constraints and proteomics data into such models was first enabled by the GECKO toolbox, allowing the study of phenotypes...

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Bibliographic Details
Main Authors: Iván Domenzain, Benjamín Sánchez, Mihail Anton, Eduard J. Kerkhoven, Aarón Millán-Oropeza, Céline Henry, Verena Siewers, John P. Morrissey, Nikolaus Sonnenschein, Jens Nielsen
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31421-1