Modelling the Preferential Solvation of Ferulic Acid in {2-Propanol (1) + Water (2)} Mixtures at 298.15 K

Modelling the Preferential Solvation of Ferulic Acid in {2-Propanol (1) + Water (2)} Mixtures at 298.15 K

Background: Recently Haq et al. reported the equilibrium solubility in {2-propanol (1) + water (2)} mixtures at several temperatures with some numerical correlation analysis. Nevertheless, no attempt was made to evaluate the preferential solvation of this compound by the solvents. Methods: Preferent...

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Bibliographic Details
Main Author: Abolghasem Jouyban 1,2, Fleming Martínez 3 *
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2017-12-01
Series:Pharmaceutical Sciences
Subjects:
no attempt was made to evaluate the preferential solvation of this compound by the solvents. Methods: Preferential solvation of ferulic acid in the saturated mixtures at 298.15 K was analyzed based on the inverse Kirkwood-Buff integrals as described in the literature. Results: Ferulic acid is preferentially solvated by water in water-rich mixtures (0.00 < x1 < 0.19) but preferentially solvated by 2-propanol in mixtures with composition 0.19 < x1 < 1.00. Conclusion: These results could be interpreted as a consequence of hydrophobic hydration around the non-polar groups of the solute in the former case (0.00 < x1 < 0.19). Moreover
in the last case (0.19 < x1 < 1.00)
Ferulic acid
Antibacterial-{2-Propanol (1) + water (2)} mixture
Preferential solvation
IKBI
Online Access:http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_19467_20170616195256

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http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_19467_20170616195256

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