Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association study

Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association study

Abstract Background Genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN), a major dose-limiting side-effect of paclitaxel, are not well understood. Methods We performed a genome-wide association study (GWAS) in 183 paclitaxel-treated patients to identify genetic loci associated...

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Bibliographic Details
Main Authors: Kosar Hooshmand, David Goldstein, Hannah C. Timmins, Tiffany Li, Michelle Harrison, Michael L. Friedlander, Craig R. Lewis, Justin G. Lees, Gila Moalem-Taylor, Boris Guennewig, Susanna B. Park, John B. Kwok
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Translational Medicine
Subjects:
Paclitaxel
Chemotherapy-induced Peripheral Neuropathy
Axon
Genome-wide association study
Online Access:https://doi.org/10.1186/s12967-022-03754-4

Internet

https://doi.org/10.1186/s12967-022-03754-4

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