LAT1 (SLC7A5) catalyzes copper(histidinate) transport switching from antiport to uniport mechanism

Summary: LAT1 (SLC7A5) is one of the most studied membrane transporters due to its relevance to physiology in supplying essential amino acids to brain and fetus, and to pathology being linked to nervous or embryo alterations; moreover, LAT1 over-expression is always associated with cancer developmen...

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Bibliographic Details
Main Authors: Raffaella Scanga, Mariafrancesca Scalise, Nadia Marino, Francesco Parisi, Donatella Barca, Michele Galluccio, Chiara Brunocilla, Lara Console, Cesare Indiveri
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223018151