Predicting the effects of rare genetic variants on oncogenic signaling pathways: A computational analysis of HRAS protein function

Predicting the effects of rare genetic variants on oncogenic signaling pathways: A computational analysis of HRAS protein function

The HRAS gene plays a crucial role in regulating essential cellular processes for life, and this gene's misregulation is linked to the development of various types of cancers. Nonsynonymous single nucleotide polymorphisms (nsSNPs) within the coding region of HRAS can cause detrimental mutations...

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Bibliographic Details
Main Authors: Sadaqat Ali, Usman Ali, Adeem Qamar, Imran Zafar, Muhammad Yaqoob, Qurat ul Ain, Summya Rashid, Rohit Sharma, Hiba-Allah Nafidi, Yousef A. Bin Jardan, Mohammed Bourhia
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Chemistry
Subjects:
cancer
genetic variants
mutations
oncogenic signaling pathways
SNPs
nsSNP
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1173624/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2023.1173624/full

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