Zymosan-A promotes the regeneration of intestinal stem cells by upregulating ASCL2

Abstract Intestinal stem cells (ISCs) are responsible for intestinal tissue homeostasis and are important for the regeneration of the damaged intestinal epithelia. Through the establishment of ionizing radiation (IR) induced intestinal injury model, we found that a TLR2 agonist, Zymosan-A, promoted...

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Bibliographic Details
Main Authors: Jicong Du, Lan Fang, Jianpeng Zhao, Yike Yu, Zhenlan Feng, Yuedong Wang, Ying Cheng, Bailong Li, Fu Gao, Cong Liu
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05301-x