Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

RUNX1 is a large and complex gene with two alternative promoters and multiple hematopoietic enhancers. Here the authors show that unlike smaller genes Runx1 becomes sub-compartmentalized during differentiation and gene activation. This subcompartmentalization partially depends on CTCF binding at pro...

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Detalhes bibliográficos
Main Authors: Dominic D. G. Owens, Giorgio Anselmi, A. Marieke Oudelaar, Damien J. Downes, Alessandro Cavallo, Joe R. Harman, Ron Schwessinger, Akin Bucakci, Lucas Greder, Sara de Ornellas, Danuta Jeziorska, Jelena Telenius, Jim R. Hughes, Marella F. T. R. de Bruijn
Formato: Artigo
Idioma:English
Publicado em: Nature Portfolio 2022-02-01
Colecção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-022-28376-8

Internet

https://doi.org/10.1038/s41467-022-28376-8

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