Forging of nicotine for the effective management of diabetic wounds: A hybrid of scaffold hopping and molecular dynamics simulation approaches

Forging of nicotine for the effective management of diabetic wounds: A hybrid of scaffold hopping and molecular dynamics simulation approaches

Diabetic wound (DW) is a huge threat to the health care community and is always challenging to treat. The main biochemical culprits in DW recalcitrance are elevated inflammatory mediators, proteases, cell proliferation and migration suppressors, anti-angiogenic factors, and bacterial infections. In...

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Bibliographic Details
Main Authors: Bharat Kumar Reddy. Sanapalli, Vidyasrilekha. Yele, Dilep Kumar. Sigalapalli, Nikhil Gadewal, Afzal B. Shaik, Richie R. Bhandare, Sivakumar. Annadurai, Veera Venkata Satyanarayana Reddy. Karri
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Arabian Journal of Chemistry
Subjects:
Diabetic wound
Nicotine
Scaffold hopping
Molecular docking
Molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535221006006

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http://www.sciencedirect.com/science/article/pii/S1878535221006006

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