Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteristic of alcohol metabolism given excessive...

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Main Authors: Rubén Rodríguez-Agudo, Irene González-Recio, Marina Serrano-Maciá, Miren Bravo, Petar Petrov, Delia Blaya, Jose María Herranz, María Mercado-Gómez, Claudia María Rejano-Gordillo, Sofía Lachiondo-Ortega, Clàudia Gil-Pitarch, Mikel Azkargorta, Sebastiaan Martijn Van Liempd, Luis Alfonso Martinez-Cruz, A.L. Simão, Félix Elortza, César Martín, Yulia A. Nevzorova, Francisco Javier Cubero, Teresa C. Delgado, Josepmaria Argemi, Ramón Bataller, Kristina Schoonjans, Jesús M. Banales, Rui E. Castro, Pau Sancho-Bru, Matías A. Avila, Josep Julve, Ramiro Jover, Jon Mabe, Jorge Simon, Naroa Goikoetxea-Usandizaga, María L. Martínez-Chantar
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:JHEP Reports
Subjects:
Alcohol-related liver disease
NIAAA model
microRNA
SIRT1
Nicotinamide adenine dinucleotide salvage pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923002495

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http://www.sciencedirect.com/science/article/pii/S2589555923002495

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