Integrated Excitatory/Inhibitory Imbalance and Transcriptomic Analysis Reveals the Association between Dysregulated Synaptic Genes and Anesthetic-Induced Cognitive Dysfunction

Integrated Excitatory/Inhibitory Imbalance and Transcriptomic Analysis Reveals the Association between Dysregulated Synaptic Genes and Anesthetic-Induced Cognitive Dysfunction

Emerging evidence from human epidemiologic and animal studies has demonstrated that developmental anesthesia neurotoxicity could cause long-term cognitive deficits and behavioral problems. However, the underlying mechanisms remain largely unknown. We conducted an electrophysiological analysis of syn...

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Bibliographic Details
Main Authors: Yasheng Yan, Sarah Logan, Xiaojie Liu, Bixuan Chen, Congshan Jiang, Thiago Arzua, Ramani Ramchandran, Qing-song Liu, Xiaowen Bai
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
propofol
excitatory and inhibitory imbalance
transcriptomic
synaptic genes
cognitive dysfunction
Online Access:https://www.mdpi.com/2073-4409/11/16/2497

Internet

https://www.mdpi.com/2073-4409/11/16/2497

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