The role of autophagy in the cytotoxicity induced by trastuzumab emtansine (T-DM1) in HER2-positive breast cancer cells
Abstract Trastuzumab emtansine (T-DM1), an antibody–drug conjugate (ADC) of trastuzumab and cytotoxic agent emtansine (DM1), has been approved for the therapy of metastatic HER2-positive breast cancer after prior treatment of trastuzumab and taxane. The impressive efficacy exhibited by T-DM1 has hei...
| Главные авторы: | , , , , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
SpringerOpen
2020-06-01
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| Серии: | AMB Express |
| Предметы: | |
| Online-ссылка: | http://link.springer.com/article/10.1186/s13568-020-01044-0 |