The role of autophagy in the cytotoxicity induced by trastuzumab emtansine (T-DM1) in HER2-positive breast cancer cells

The role of autophagy in the cytotoxicity induced by trastuzumab emtansine (T-DM1) in HER2-positive breast cancer cells

Abstract Trastuzumab emtansine (T-DM1), an antibody–drug conjugate (ADC) of trastuzumab and cytotoxic agent emtansine (DM1), has been approved for the therapy of metastatic HER2-positive breast cancer after prior treatment of trastuzumab and taxane. The impressive efficacy exhibited by T-DM1 has hei...

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Những tác giả chính: Peipei Liu, Jiajun Fan, Ziyu Wang, Wenjing Zai, Ping Song, Yongping Li, Dianwen Ju
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: SpringerOpen 2020-06-01
Loạt:AMB Express
Những chủ đề:
Trastuzumab emtansine
Autophagy
Apoptosis
Autophagy inhibition
Truy cập trực tuyến:http://link.springer.com/article/10.1186/s13568-020-01044-0

Internet

http://link.springer.com/article/10.1186/s13568-020-01044-0

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