Direct Conversion of 3-(2-Nitroethyl)-1<i>H</i>-Indoles into 2-(1<i>H</i>-Indol-2-yl)Acetonitriles

Direct Conversion of 3-(2-Nitroethyl)-1<i>H</i>-Indoles into 2-(1<i>H</i>-Indol-2-yl)Acetonitriles

The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1<i>H</i>-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1<i>H</i>-indole byproducts. Herein, we off...

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Bibliographic Details
Main Authors: Alexander V. Aksenov, Nicolai A. Aksenov, Elena V. Aleksandrova, Dmitrii A. Aksenov, Igor Yu. Grishin, Elena A. Sorokina, Allison Wenger, Michael Rubin
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
nitroalkanes
heterocycles
1,2-alkyl shift
rearrangements
cascade transformations
Online Access:https://www.mdpi.com/1420-3049/26/20/6132

Internet

https://www.mdpi.com/1420-3049/26/20/6132

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