Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of polyelectrolyte complex (PEC) nanoparticle (NP) bas...

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Bibliographic Details
Main Authors: David Vehlow, Jeremy P. H. Wong, Birgit Urban, Janek Weißpflog, Annett Gebert, Matthias Schumacher, Michael Gelinsky, Manfred Stamm, Martin Müller
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceutics
Subjects:
catechol
DOPAC
bortezomib
multiple myeloma
polyelectrolyte complex nanoparticle
drug delivery
Online Access:https://www.mdpi.com/1999-4923/12/9/799

Internet

https://www.mdpi.com/1999-4923/12/9/799

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