Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway

Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway

Abstract Background Fibronectin, an extracellular matrix protein, has been reported to be associated with heterogeneous cancer stemness, angiogenesis and progression in multiple cancer types. However, the roles and the underlying mechanism of fibronectin on the progression NSCLC need to be further e...

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Bibliographic Details
Main Authors: Fei Zhou, Jianguo Sun, Lingyun Ye, Tao Jiang, Wei Li, Chunxia Su, Shengxiang Ren, Fengying Wu, Caicun Zhou, Guanghui Gao
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Experimental Hematology & Oncology
Subjects:
Fibronectin
NSCLC
Metastasis
Angiogenesis
WISP3
MAPK/ERK
Online Access:https://doi.org/10.1186/s40164-023-00419-w

Internet

https://doi.org/10.1186/s40164-023-00419-w

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