Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets
Chronic pain has been proven to be an independent disease, other than an accompanying symptom of certain diseases. Interleukin-18 (IL-18), a pro-inflammatory cytokine with pleiotropic biological effects, participates in immune modulation, inflammatory response, tumor growth, as well as the process o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824000331 |
| _version_ | 1797291816455766016 |
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| author | Jie Ju Zheng Li Xiaoqian Jia Xiaoling Peng Jihong Wang Feng Gao |
| author_facet | Jie Ju Zheng Li Xiaoqian Jia Xiaoling Peng Jihong Wang Feng Gao |
| author_sort | Jie Ju |
| collection | DOAJ |
| description | Chronic pain has been proven to be an independent disease, other than an accompanying symptom of certain diseases. Interleukin-18 (IL-18), a pro-inflammatory cytokine with pleiotropic biological effects, participates in immune modulation, inflammatory response, tumor growth, as well as the process of chronic pain. Compelling evidence suggests that IL-18 is upregulated in the occurrence of chronic pain. Antagonism or inhibition of IL-18 expression can alleviate the occurrence and development of chronic pain. And IL-18 is located in microglia, while IL-18R is mostly located in astrocytes in the spinal cord. This indicates that the interaction between microglia and astrocytes mediated by the IL-18/IL-18R axis is involved in the occurrence of chronic pain. In this review, we described the role and mechanism of IL-18 in different types of chronic pain. This review provides strong evidence that IL-18 is a potential therapeutic target in pain management. |
| first_indexed | 2024-03-07T19:42:17Z |
| format | Article |
| id | doaj.art-2c7d7bac650c4f39b85f4d59450ae6d1 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-07T19:42:17Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-2c7d7bac650c4f39b85f4d59450ae6d12024-02-29T05:18:08ZengElsevierPharmacological Research1096-11862024-03-01201107089Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targetsJie Ju0Zheng Li1Xiaoqian Jia2Xiaoling Peng3Jihong Wang4Feng Gao5Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCorrespondence to: Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan 430030, China.; Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaChronic pain has been proven to be an independent disease, other than an accompanying symptom of certain diseases. Interleukin-18 (IL-18), a pro-inflammatory cytokine with pleiotropic biological effects, participates in immune modulation, inflammatory response, tumor growth, as well as the process of chronic pain. Compelling evidence suggests that IL-18 is upregulated in the occurrence of chronic pain. Antagonism or inhibition of IL-18 expression can alleviate the occurrence and development of chronic pain. And IL-18 is located in microglia, while IL-18R is mostly located in astrocytes in the spinal cord. This indicates that the interaction between microglia and astrocytes mediated by the IL-18/IL-18R axis is involved in the occurrence of chronic pain. In this review, we described the role and mechanism of IL-18 in different types of chronic pain. This review provides strong evidence that IL-18 is a potential therapeutic target in pain management.http://www.sciencedirect.com/science/article/pii/S1043661824000331Interleukin-18Chronic painNeuropathic painCancer painCentral poststroke painPolyneuropathy |
| spellingShingle | Jie Ju Zheng Li Xiaoqian Jia Xiaoling Peng Jihong Wang Feng Gao Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets Pharmacological Research Interleukin-18 Chronic pain Neuropathic pain Cancer pain Central poststroke pain Polyneuropathy |
| title | Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets |
| title_full | Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets |
| title_fullStr | Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets |
| title_full_unstemmed | Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets |
| title_short | Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets |
| title_sort | interleukin 18 in chronic pain focus on pathogenic mechanisms and potential therapeutic targets |
| topic | Interleukin-18 Chronic pain Neuropathic pain Cancer pain Central poststroke pain Polyneuropathy |
| url | http://www.sciencedirect.com/science/article/pii/S1043661824000331 |
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