Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma

Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma

Abstract Dysregulation of wild-type p53 turnover is a key cause of hepatocellular carcinoma (HCC), yet its mechanism remains poorly understood. Here, we report that WD repeat and SOCS box containing protein 2 (WSB2), an E3 ubiquitin ligase, is an independent adverse prognostic factor in HCC patients...

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Bibliographic Details
Main Authors: Xun Li, Cheng-Cheng Zhang, Xiao-Tong Lin, Jie Zhang, Yu-Jun Zhang, Hong-Qiang Yu, Ze-Yu Liu, Yi Gong, Lei-Da Zhang, Chuan-Ming Xie
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-01142-6

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https://doi.org/10.1038/s12276-023-01142-6

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