Metabolomics and integrated network pharmacology analysis reveal SNKAF decoction suppresses cell proliferation and induced cell apoptisis in hepatocellular carcinoma via PI3K/Akt/P53/FoxO signaling axis

Metabolomics and integrated network pharmacology analysis reveal SNKAF decoction suppresses cell proliferation and induced cell apoptisis in hepatocellular carcinoma via PI3K/Akt/P53/FoxO signaling axis

Abstract Background There is no comprehensive treatment method for hepatocellular carcinoma (HCC); hence, research and development are still focused on systemic therapies, including drugs. Sinikangai fang (SNKAF) decoction, a classic Chinese herbal prescription, has been widely used to treat liver c...

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Bibliographic Details
Main Authors: Wei Guo, Xiaohui Yao, Siyuan Lan, Chi Zhang, Hanhan Li, Zhuangzhong Chen, Ling Yu, Guanxian Liu, Yuan Lin, Shan Liu, Hanrui Chen
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Chinese Medicine
Subjects:
Hepatocellular carcinoma
Network pharmacology
Metabolomic analysis
SNKAF decoction
PI3K/Akt/P53/FoxO signaling pathway axis
Online Access:https://doi.org/10.1186/s13020-022-00628-1

Internet

https://doi.org/10.1186/s13020-022-00628-1

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