Genetic Blockade of NAAA Cell-specifically Regulates Fatty Acid Ethanolamides (FAEs) Metabolism and Inflammatory Responses

Genetic Blockade of NAAA Cell-specifically Regulates Fatty Acid Ethanolamides (FAEs) Metabolism and Inflammatory Responses

N-Acylethanolamine acid amidase (NAAA) is a lysosomal enzyme responsible for the hydrolysis of fatty acid ethanolamides (FAEs). However, the role of NAAA in FAEs metabolism and regulation of pain and inflammation remains mostly unknown. Here, we generated NAAA-deficient (NAAA-/-) mice using CRISPR-C...

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Bibliographic Details
Main Authors: Xiaohua Xie, Yitian Li, Sennan Xu, Pan Zhou, Longhe Yang, Yaping Xu, Yan Qiu, Yungang Yang, Yuhang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
N-acylethanolamine acid amidase (NAAA)
fatty acid ethanolamides (FAEs)
anandamide (AEA)
palmitoylethanolamide (PEA)
analgesic tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.817603/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.817603/full

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