Genetic Blockade of NAAA Cell-specifically Regulates Fatty Acid Ethanolamides (FAEs) Metabolism and Inflammatory Responses

Genetic Blockade of NAAA Cell-specifically Regulates Fatty Acid Ethanolamides (FAEs) Metabolism and Inflammatory Responses

N-Acylethanolamine acid amidase (NAAA) is a lysosomal enzyme responsible for the hydrolysis of fatty acid ethanolamides (FAEs). However, the role of NAAA in FAEs metabolism and regulation of pain and inflammation remains mostly unknown. Here, we generated NAAA-deficient (NAAA-/-) mice using CRISPR-C...

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Autori principali: Xiaohua Xie, Yitian Li, Sennan Xu, Pan Zhou, Longhe Yang, Yaping Xu, Yan Qiu, Yungang Yang, Yuhang Li
Natura: Articolo
Lingua:English
Pubblicazione: Frontiers Media S.A. 2022-01-01
Serie:Frontiers in Pharmacology
Soggetti:
N-acylethanolamine acid amidase (NAAA)
fatty acid ethanolamides (FAEs)
anandamide (AEA)
palmitoylethanolamide (PEA)
analgesic tolerance
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2021.817603/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.817603/full

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