Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2

Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2

Summary: Background: To address the emergence of SARS-CoV-2, multiple clinical trials in humans were rapidly started, including those involving an oral treatment by nitazoxanide, despite no or limited pre-clinical evidence of antiviral efficacy. Methods: In this work, we present a complete pre-clin...

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Bibliographic Details
Main Authors: Jean-Sélim Driouich, Maxime Cochin, Franck Touret, Paul-Rémi Petit, Magali Gilles, Grégory Moureau, Karine Barthélémy, Caroline Laprie, Thanaporn Wattanakul, Palang Chotsiri, Richard M. Hoglund, Joel Tarning, Laurent Fraisse, Peter Sjö, Charles E. Mowbray, Fanny Escudié, Ivan Scandale, Eric Chatelain, Xavier de Lamballerie, Caroline Solas, Antoine Nougairède
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:EBioMedicine
Subjects:
COVID-19
SARS-CoV-2
Antiviral therapy
Pre-clinical research
Nitazoxanide
Animal model
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422003292

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http://www.sciencedirect.com/science/article/pii/S2352396422003292

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