A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau

A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau

Abstract Background Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer’s disease (AD). However, mouse models imitating AD-exclusive neuronal tau pathologies are lacking. Methods We generated a new tet-on transgenic mouse model expressing truncated human tau N1-...

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Bibliographic Details
Main Authors: Yang Gao, Yuying Wang, Huiyang Lei, Zhendong Xu, Shihong Li, Haitao Yu, Jiazhao Xie, Zhentao Zhang, Gongping Liu, Yao Zhang, Jie Zheng, Jian-Zhi Wang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Animal model
Tau hyperphosphorylation
Truncated tau
Tet-on system
Online Access:https://doi.org/10.1186/s40035-023-00379-5

Internet

https://doi.org/10.1186/s40035-023-00379-5

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