A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei Infection

A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei Infection

In many infectious diseases, the immune response operates as a double-edged sword. While required for protective immunity, infection-induced inflammation can be detrimental if it is not properly controlled, causing collateral body damage and potentially leading to death. It is in this context that t...

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Bibliographic Details
Main Authors: Carl De Trez, Benoit Stijlemans, Viki Bockstal, Jennifer Cnops, Hannelie Korf, Jacques Van Snick, Guy Caljon, Eric Muraille, Ian R. Humphreys, Louis Boon, Jo A. Van Ginderachter, Stefan Magez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
T. brucei
IL-10
inflammation
T cells
IL-27
Blimp-1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01085/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01085/full

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