Adoptive Immunotherapy With Engineered iNKT Cells to Target Cancer Cells and the Suppressive Microenvironment

Adoptive Immunotherapy With Engineered iNKT Cells to Target Cancer Cells and the Suppressive Microenvironment

Invariant Natural Killer T (iNKT) cells are T lymphocytes expressing a conserved semi-invariant TCR specific for lipid antigens (Ags) restricted for the monomorphic MHC class I-related molecule CD1d. iNKT cells infiltrate mouse and human tumors and play an important role in the immune surveillance a...

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Bibliographic Details
Main Authors: Gloria Delfanti, Paolo Dellabona, Giulia Casorati, Maya Fedeli
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Medicine
Subjects:
NKT cells
CD1d
cancer immunotherapy
CAR
T cell receptor
adoptive cell therapy (ACT)
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.897750/full

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https://www.frontiersin.org/articles/10.3389/fmed.2022.897750/full

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