Outer membrane and phospholipid composition of the target membrane affect the antimicrobial potential of first- and second-generation lipophosphonoxins

Outer membrane and phospholipid composition of the target membrane affect the antimicrobial potential of first- and second-generation lipophosphonoxins

Abstract Lipophosphonoxins (LPPOs) are small modular synthetic antibacterial compounds that target the cytoplasmic membrane. First-generation LPPOs (LPPO I) exhibit an antimicrobial activity against Gram-positive bacteria; however they do not exhibit any activity against Gram-negatives. Second-gener...

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Bibliographic Details
Main Authors: Klára Látrová, Noemi Havlová, Renata Večeřová, Dominik Pinkas, Kateřina Bogdanová, Milan Kolář, Radovan Fišer, Ivo Konopásek, Duy Dinh Do Pham, Dominik Rejman, Gabriela Mikušová
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89883-0

Internet

https://doi.org/10.1038/s41598-021-89883-0

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