Induction of Apoptosis by a Combination of 2-Deoxyglucose and Metformin in Esophageal Squamous Cell Carcinoma by Targeting Cancer Cell Metabolism

Induction of Apoptosis by a Combination of 2-Deoxyglucose and Metformin in Esophageal Squamous Cell Carcinoma by Targeting Cancer Cell Metabolism

Background: Both mitochondrial dysfunction and aerobic glycolysis are signs of growing aggressive cancer. If altered metabolism of cancer cell is intended, using the glycolysis inhibitor (2-deoxyglucose (2DG)) would be a viable therapeutic method. The AMP-activated protein kinase (AMPK), as a metabo...

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Bibliographic Details
Main Authors: Abbas Shafaee, Jalil Pirayesh Islamian, Davoud Zarei, Mohsen Mohammadi, Kazem Nejati-Koshki, Alireza Farajollahi, Seyed Mahmoud Reza Aghamiri, Mohammad Rahmati Yamchi, Behzad Baradaran, Mohammad Asghari Jafarabadi
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2019-03-01
Series:Iranian Journal of Medical Sciences
Subjects:
2-Deoxy-D-Glucose
Esophageal carcinoma
Metformin
apoptosis
Online Access:http://ijms.sums.ac.ir/article_44522_7ab70849b19909ee8dd86b721e96daba.pdf

Internet

http://ijms.sums.ac.ir/article_44522_7ab70849b19909ee8dd86b721e96daba.pdf

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