Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

Epigenetic modifiers are an emerging class of anti-tumor drugs, potent in multiple cancer contexts. Their effect on spontaneously developing autoimmune diseases has been little explored. We report that a short treatment with I-BET151, a small-molecule inhibitor of a family of bromodomain-containing...

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Bibliographic Details
Main Authors: Wenxian Fu, Julia Farache, Susan M Clardy, Kimie Hattori, Palwinder Mander, Kevin Lee, Inmaculada Rioja, Ralph Weissleder, Rab K Prinjha, Christophe Benoist, Diane Mathis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
autoimmune diabetes
bromodomain inhibitor
NF-KB
Online Access:https://elifesciences.org/articles/04631

Internet

https://elifesciences.org/articles/04631

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