Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells

Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells

HIV-associated cognitive dysfunction during combination antiretroviral therapy (cART) involves mitochondrial dysfunction, but the impact of contemporary cART on chronic metabolic changes in the brain and in latent HIV infection is unclear. We interrogated mitochondrial function in a human microglia...

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Bibliographic Details
Main Authors: Harpreet Kaur, Paige Minchella, David Alvarez-Carbonell, Neeraja Purandare, Vijay K. Nagampalli, Daniel Blankenberg, Todd Hulgan, Mariana Gerschenson, Jonathan Karn, Siddhesh Aras, Asha R. Kallianpur
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
HIV
antiretroviral drug
combination antiretroviral therapy
mitochondrial dysfunction
human microglia
iron
Online Access:https://www.mdpi.com/1422-0067/24/15/12242

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https://www.mdpi.com/1422-0067/24/15/12242

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