Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer’s disease-like pathology

Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer’s disease-like pathology

Abstract Background Amyloid β (Aβ)-directed immunotherapy has shown promising results in preclinical and early clinical Alzheimer’s disease (AD) trials, but successful translation to late clinics has failed so far. Compelling evidence suggests that post-translationally modified Aβ peptides might pla...

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Bibliographic Details
Main Authors: Kathrin Gnoth, Anke Piechotta, Martin Kleinschmidt, Sandra Konrath, Mathias Schenk, Nadine Taudte, Daniel Ramsbeck, Vera Rieckmann, Stefanie Geissler, Rico Eichentopf, Susan Barendrecht, Maike Hartlage-Rübsamen, Hans-Ulrich Demuth, Steffen Roßner, Holger Cynis, Jens-Ulrich Rahfeld, Stephan Schilling
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Passive immunotherapy
Isoaspartate
Amyloid beta
5xFAD mouse model
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13195-020-00719-x

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http://link.springer.com/article/10.1186/s13195-020-00719-x

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