Development of a highly sensitive chemiluminescence immunoassay for quantification of aggrecanase-generated ARGS aggrecan fragments in serum

Development of a highly sensitive chemiluminescence immunoassay for quantification of aggrecanase-generated ARGS aggrecan fragments in serum

Objective: Cartilage degradation is a hallmark of osteoarthritis (OA). Aggrecan, a major proteoglycan of articular cartilage extracellular matrix (ECM), is degraded by ADAMTS-5 resulting in the release of ARGS-G2 fragments to synovial fluid and circulation. The aim was to quantify ARGS-G2 in the ser...

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Bibliographic Details
Main Authors: Yi He, Kamilla E. Jensen, Anne Sofie Siebuhr, Morten A. Karsdal, Jonathan Larkin, Anne C. Bay-Jensen
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Aggrecan
ADAMTS-5
Immunoassay
ARGS
Knee osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S266591312100025X

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http://www.sciencedirect.com/science/article/pii/S266591312100025X

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