Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway

Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway

Spinal cord injury (SCI) is a high incident rate of central nervous system disease that usually causes paralysis below the injured level. The occurrence of chronic inflammation with the axonal regeneration difficulties are the underlying barriers for the recovery of SCI patients. Current studies hav...

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Bibliographic Details
Main Authors: Ruihua Fan, Lvxia Wang, Benson O. A. Botchway, Yong Zhang, Xuehong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
spinal cord injury
ethyl pyruvate
high mobility group box-1 (HMGB1)
toll-like receptors (TLRs)
nuclear factor-kappa B (NF-κB)
astrocytic activation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1013033/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.1013033/full

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