<i>cd</i><sup>1</sup> Mutation in <i>Drosophila</i> Affects Phenoxazinone Synthase Catalytic Site and Impairs Long-Term Memory

<i>cd</i><sup>1</sup> Mutation in <i>Drosophila</i> Affects Phenoxazinone Synthase Catalytic Site and Impairs Long-Term Memory

Being involved in development of Huntington’s, Parkinson’s and Alzheimer’s diseases, kynurenine pathway (KP) of tryptophan metabolism plays a significant role in modulation of neuropathology. Accumulation of a prooxidant 3-hydroxykynurenine (3-HOK) leads to oxidative stress and neuronal cell apoptos...

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Bibliographic Details
Main Authors: Aleksandr V. Zhuravlev, Polina N. Ivanova, Ksenia A. Makaveeva, Gennadii A. Zakharov, Ekaterina A. Nikitina, Elena V. Savvateeva-Popova
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Drosophila</i>
<i>cardinal</i>
3-hydroxykynurenine
phenoxazinone synthase
courtship suppression
long-term memory
Online Access:https://www.mdpi.com/1422-0067/23/20/12356

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https://www.mdpi.com/1422-0067/23/20/12356

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