Development of a Predictive Dosing Nomogram to Achieve PK/PD Targets of Amikacin Initial Dose in Critically Ill Patients: A Non-Parametric Approach

French guidelines recommend reaching an amikacin concentration of ≥8 × MIC 1 h after beginning infusion (C<sub>1h</sub>), with MIC = 8 mg/L for probabilistic therapy. We aimed to elaborate a nomogram guiding clinicians in choosing the right first amikacin dose for ICU patients in septic...

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Bibliographic Details
Main Authors: Anne Coste, Ronan Bellouard, Guillaume Deslandes, Laurence Jalin, Claire Roger, Séverine Ansart, Eric Dailly, Cédric Bretonnière, Matthieu Grégoire
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antibiotics
Subjects:
Online Access:https://www.mdpi.com/2079-6382/12/1/123