Differential Effects of Hypoxia versus Hyperoxia or Physoxia on Phenotype and Energy Metabolism in Human Chondrocytes from Osteoarthritic Compared to Macroscopically Normal Cartilage

Differential Effects of Hypoxia versus Hyperoxia or Physoxia on Phenotype and Energy Metabolism in Human Chondrocytes from Osteoarthritic Compared to Macroscopically Normal Cartilage

Chondrocyte phenotype and energy metabolism are altered in osteoarthritis (OA). However, most studies characterising the change in human chondrocyte behaviour in OA have been conducted in supraphysiological oxygen concentrations. The purpose of this study was to compare phenotype and energy metaboli...

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Bibliographic Details
Main Authors: Lekha Jain, Scott M. Bolam, A. Paul Monk, Jacob T. Munro, Even Chen, Jade Tamatea, Nicola Dalbeth, Raewyn C. Poulsen
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
glycolysis
oxidative phosphorylation
hypoxia
physoxia
chondrocyte
osteoarthritis
Online Access:https://www.mdpi.com/1422-0067/24/8/7532

Internet

https://www.mdpi.com/1422-0067/24/8/7532

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