Insulinotropic Effects of Neprilysin and/or Angiotensin Receptor Inhibition in Mice

Insulinotropic Effects of Neprilysin and/or Angiotensin Receptor Inhibition in Mice

Treatment of heart failure with the angiotensin receptor-neprilysin inhibitor sacubitril/valsartan improved glycemic control in individuals with type 2 diabetes. The relative contribution of neprilysin inhibition versus angiotensin II receptor antagonism to this glycemic benefit remains unknown. Thu...

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Bibliographic Details
Main Authors: Nathalie Esser, Christine Schmidt, Breanne M. Barrow, Laura Cronic, Daryl J. Hackney, Stephen M. Mongovin, Meghan F. Hogan, Andrew T. Templin, Joseph J. Castillo, Rebecca L. Hull, Sakeneh Zraika
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Endocrinology
Subjects:
angiotensin receptor-neprilysin inhibitor
insulin secretion
renin-angiotensin system
obesity
type 2 diabetes
sacubitril
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.888867/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.888867/full

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