Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice

Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice

Microglia activity can drive excessive synaptic loss during the prodromal phase of Alzheimer’s disease (AD) and is associated with lowered cyclic adenosine monophosphate (cAMP) due to cAMP phosphodiesterase 4B (PDE4B). This study aimed to investigate whether long-term inhibition of PDE4B by A33 (3 m...

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Bibliographic Details
Main Authors: Ben Rombaut, Melissa Schepers, Assia Tiane, Femke Mussen, Lisa Koole, Sofie Kessels, Chloë Trippaers, Ruben Jacobs, Kristiaan Wouters, Emily Willems, Lieve van Veggel, Philippos Koulousakis, Dorien Deluyker, Virginie Bito, Jos Prickaerts, Inez Wens, Bert Brône, Daniel L. A. van den Hove, Tim Vanmierlo
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Cells
Subjects:
Alzheimer’s disease
cyclic nucleotide phosphodiesterases type 4B
synapse
microglia
cognition
Online Access:https://www.mdpi.com/2073-4409/13/12/1000

Internet

https://www.mdpi.com/2073-4409/13/12/1000

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