Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice

Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice

Microglia activity can drive excessive synaptic loss during the prodromal phase of Alzheimer’s disease (AD) and is associated with lowered cyclic adenosine monophosphate (cAMP) due to cAMP phosphodiesterase 4B (PDE4B). This study aimed to investigate whether long-term inhibition of PDE4B by A33 (3 m...

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Hlavní autoři: Ben Rombaut, Melissa Schepers, Assia Tiane, Femke Mussen, Lisa Koole, Sofie Kessels, Chloë Trippaers, Ruben Jacobs, Kristiaan Wouters, Emily Willems, Lieve van Veggel, Philippos Koulousakis, Dorien Deluyker, Virginie Bito, Jos Prickaerts, Inez Wens, Bert Brône, Daniel L. A. van den Hove, Tim Vanmierlo
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2024-06-01
Edice:Cells
Témata:
Alzheimer’s disease
cyclic nucleotide phosphodiesterases type 4B
synapse
microglia
cognition
On-line přístup:https://www.mdpi.com/2073-4409/13/12/1000

Internet

https://www.mdpi.com/2073-4409/13/12/1000

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