Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes severe disease in humans with case-fatality rates of up to 30%. There are currently very limited treatment options for SFTSV infection. We conducted a drug repurposing program by establishing a...

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Bibliographic Details
Main Authors: Shuofeng Yuan, Jasper Fuk-Woo Chan, Zi-Wei Ye, Lei Wen, Terance Gi-Wai Tsang, Jianli Cao, Jingjing Huang, Chris Chun-Yiu Chan, Kenn Ka-Heng Chik, Garnet Kwan-Yue Choi, Jian-Piao Cai, Feifei Yin, Hin Chu, Mifang Liang, Dong-Yan Jin, Kwok-Yung Yuen
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Viruses
Subjects:
antiviral
broxyquinoline
bunyavirales
eltrombopag
entry
hexachlorophene
Huaiyangshan banyangvirus
regorafenib
SFTSV
triclosan
Online Access:https://www.mdpi.com/1999-4915/11/4/385

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https://www.mdpi.com/1999-4915/11/4/385

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