Human CD141+ Dendritic Cell and CD1c+ Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo

Human CD141+ Dendritic Cell and CD1c+ Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo

Human immune cell subsets develop in immunodeficient mice following reconstitution with human CD34+ hematopoietic stem cells. These “humanized” mice are useful models to study human immunology and human-tropic infections, autoimmunity, and cancer. However, some human immune cell subsets are unable t...

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Bibliographic Details
Main Authors: Yoshihito Minoda, Isaac Virshup, Ingrid Leal Rojas, Oscar Haigh, Yide Wong, John J. Miles, Christine A. Wells, Kristen J. Radford
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
humanized mice
dendritic cells
CD141+ DC
CD1c+ DC
poly I:C
R848
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01419/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01419/full

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