CAR-tropic extracellular vesicles carry tumor-associated antigens and modulate CAR T cell functionality

CAR-tropic extracellular vesicles carry tumor-associated antigens and modulate CAR T cell functionality

Abstract Tumor-derived extracellular vesicles (EVs) are active contributors in metastasis and immunosuppression in tumor microenvironment. At least some of the EVs carry tumor surface molecules such as tumor-associated antigens (TAAs) and/or checkpoint inhibitors, and potentially could interact with...

Full description

Bibliographic Details
Main Authors: V. M. Ukrainskaya, O. E. Musatova, D. V. Volkov, D. S. Osipova, D. S. Pershin, A. M. Moysenovich, E. G. Evtushenko, E. A. Kulakovskaya, E. G. Maksimov, H. Zhang, Y. P. Rubtsov, M. A. Maschan, A. V. Stepanov, A. G. Gabibov
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-27604-5

Internet

https://doi.org/10.1038/s41598-023-27604-5

Similar Items