SOCS domain targets ECM assembly in lung fibroblasts and experimental lung fibrosis

SOCS domain targets ECM assembly in lung fibroblasts and experimental lung fibrosis

Abstract Idiopathic pulmonary fibrosis (IPF) is a fatal disease defined by a progressive decline in lung function due to scarring and accumulation of extracellular matrix (ECM) proteins. The SOCS (Suppressor Of Cytokine Signaling) domain is a 40 amino acid conserved domain known to form a functional...

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Bibliographic Details
Main Authors: Carina Magdaleno, Daniel J. Tschumperlin, Narendiran Rajasekaran, Archana Varadaraj
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
ECM
Fibroblast
SOCS domain
Fibronectin
Myofibroblast
Online Access:https://doi.org/10.1038/s41598-024-83187-9

Internet

https://doi.org/10.1038/s41598-024-83187-9

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