In vitro testing of host-targeting small molecule antiviral matriptase/TMPRSS2 inhibitors in 2D and 3D cell-based assays

In vitro testing of host-targeting small molecule antiviral matriptase/TMPRSS2 inhibitors in 2D and 3D cell-based assays

The outbreak of coronavirus disease 2019 (COVID-19) pandemic strongly stimulated the development of small molecule antivirals selectively targeting type II transmembrane serine proteases (TTSP), required for the host-cell entry of numerous viruses. A set of 3-amidinophenylalanine derivatives (MI-21,...

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Bibliographic Details
Main Authors: Nicholas van Eijk, Luna C. Schmacke, Torsten Steinmetzer, Oliver Pilgram, Miklós Poór, Erzsébet Pászti-Gere
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
TMPRSS2
3D Matrigel
SARS-CoV-2
Protein binding
Cytochrome P450 3A4
Primary human hepatocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223015597

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http://www.sciencedirect.com/science/article/pii/S0753332223015597

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